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Neural Computation, Vol 9, 533-553, Copyright © 1997 by The MIT Press

LETTERS

Possible Roles of Spontaneous Waves and Dendritic Growth for Retinal Receptive Field Development

Pierre-Yves Burgi and Norberto M. Grzywacz

Several models of cortical development postulate that a Hebbian process fed by spontaneous activity amplifies orientation biases occurring randomly in early wiring, to form orientation selectivity. These models are not applicable to the development of retinal orientation selectivity, since they neglect the polarization of the retina's poorly branched early dendritic trees and the wavelike organization of the retina's early noise. There is now evidence that dendritic polarization and spontaneous waves are key in the development of retinal receptive fields. Whenmodels of cortical development are modified to take these factors into account, one obtains a model of retinal development in which early dendritic polarization is the seed of orientation selectivity, while the spatial extent of spontaneous waves controls the spatial profile of receptive fields and their tendency to be isotropic.


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Copyright © 1997 by The MIT Press.