HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nomura, M. Articles by Aoyagi, T. Search for Related Content PubMed PubMed Citation Articles by Nomura, M. Articles by Aoyagi, T.

Synchrony of Fast-Spiking Interneurons Interconnected by GABAergic and Electrical Synapses

nomura{at}acs.i.kyoto-u.ac.jp, Department of Applied Analysis and Complex Dynamical Systems, Graduate School of Informatics, Kyoto University, Kyoto 606-8501, Japan, and CREST, Japan Science and Technology Corporation, Kawaguchi, Saitama 332-0012, Japan

Tomoki Fukai

tfukai{at}eng.tamagawa.ac.jp, Department of Information-Communication Engineering, Tamagawa University, Tokyo 194-8610, Japan; CREST, Japan Science and Technology Corporation, Kawaguchi, Saitama 332-0012, Japan

Toshio Aoyagi

aoyagi{at}acs.i.kyoto-u.ac.jp, Department of Applied Analysis and Complex Dynamical Systems, Graduate School of Informatics, Kyoto University, Kyoto 606-8501, Japan, and CREST, Japan Science and Technology Corporation, Kawaguchi, Saitama 332-0012, Japan

Fast-spiking (FS) interneurons have specific types (Kv3.1/3.2 type) of the delayed potassium channel, which differ from the conventional Hodgkin-Huxley (HH) type potassium channel (Kv1.3 type) in several aspects. In this study, we show dramatic effects of the Kv3.1/3.2 potassium channel on the synchronization of the FS interneurons. We show analytically that two identical electrically coupled FS interneurons modeled with Kv3.1/3.2 channel fire synchronously at arbitrary firing frequencies, unlike similarly coupled FS neurons modeled with Kv1.3 channel that show frequency-dependent synchronous and antisynchronous firing states. Introducing GABA_A receptor-mediated synaptic connections into an FS neuron pair tends to induce an antisynchronous firing state, even if the chemical synapses are bidirectional. Accordingly, an FS neuron pair connected simultaneously by electrical and chemical synapses achieves both synchronous firing state and antisynchronous firing state in a physiologically plausible range of the conductance ratio between electrical and chemical synapses. Moreover, we find that a large-scale network of FS interneurons connected by gap junctions and bidirectional GABAergic synapses shows similar bistability in the range of gamma frequencies (30–70 Hz).

This article has been cited by other articles:

				C. I. Buia and P. H. Tiesinga Role of Interneuron Diversity in the Cortical Microcircuit for Attention J Neurophysiol, May 1, 2008; 99(5): 2158 - 2182. [Abstract] [Full Text] [PDF]

				J. G. Mancilla, T. J. Lewis, D. J. Pinto, J. Rinzel, and B. W. Connors Synchronization of Electrically Coupled Pairs of Inhibitory Interneurons in Neocortex J. Neurosci., February 21, 2007; 27(8): 2058 - 2073. [Abstract] [Full Text] [PDF]

				T. Kanamaru Analysis of synchronization between two modules of pulse neural networks with excitatory and inhibitory connections. Neural Comput., May 1, 2006; 18(5): 1111 - 1131. [Abstract] [Full Text] [PDF]

				C. Geisler, N. Brunel, and X.-J. Wang Contributions of Intrinsic Membrane Dynamics to Fast Network Oscillations With Irregular Neuronal Discharges J Neurophysiol, December 1, 2005; 94(6): 4344 - 4361. [Abstract] [Full Text] [PDF]

				E. B. Merriam, T. I. Netoff, and M. I. Banks Bistable Network Behavior of Layer I Interneurons in Auditory Cortex J. Neurosci., June 29, 2005; 25(26): 6175 - 6186. [Abstract] [Full Text] [PDF]

				B. Pfeuty, G. Mato, D. Golomb, and D. Hansel The Combined Effects of Inhibitory and Electrical Synapses in Synchrony Neural Comput., March 1, 2005; 17(3): 633 - 670. [Abstract] [Full Text] [PDF]

				N. Kopell and B. Ermentrout Chemical and electrical synapses perform complementary roles in the synchronization of interneuronal networks PNAS, October 26, 2004; 101(43): 15482 - 15487. [Abstract] [Full Text] [PDF]